Desarrollo de Materiales Poliméricos como Hidrogeles con Curcumina para Regeneración de Tejidos de la Piel

Mateo Pérez Ruiz; Miriam Veronica Flores Merino; Abraham Gonzalez Ruiz

doi:10.17488/RMIB.45.3.6

Autores/as

Mateo Pérez Ruiz Universidad Tecnológca de San Juan del Río / Universidad Autónoma del Estado de México, México https://orcid.org/0000-0002-7907-7988
Miriam Veronica Flores Merino Universidad Autónoma del Estado de México, México
Abraham Gonzalez Ruiz Instituto Nacional de Investigaciones Nucleares, México https://orcid.org/0000-0003-0059-0111

DOI:

https://doi.org/10.17488/RMIB.45.3.6

Palabras clave:

biopolímeros, curcumina, heridas crónicas, hidrogeles

Resumen

El objetivo de esta revisión es destacar los avances en el desarrollo de hidrogeles y el uso de curcumina en el tratamiento de heridas crónicas. Las heridas crónicas, como úlceras por presión, vasculares, neuropáticas y neoplásicas, representan un significativo problema de salud global, siendo entre el 1-2 % de todas las heridas que existen, y tan solo en México el 9.4 % de la población adulta padece de heridas crónicas, exacerbadas por complicaciones de la diabetes mellitus. Esta revisión sistemática se utilizó la biblioteca virtual OMICsearch y el gestor de búsqueda Mendeley, considerando investigaciones que incluyeran alguna de las palabras clave como biopolímeros, curcumina, heridas crónicas e hidrogeles., por lo que se descartó cualquiera que no se relacionara con estas y que no estuviera comprendida en el periodo de búsqueda entre 2006 y 2024. Se encontró a partir de 51 artículos seleccionados que la curcumina, un fitofármaco con propiedades antioxidantes, antiinflamatorias y proangiogénicas, ha demostrado ser eficaz en la cicatrización. Por otra parte, los hidrogeles ofrecen ventajas significativas en el tratamiento de heridas debido a su capacidad para proporcionar control espaciotemporal en las etapas de curación, regular los microambientes de las heridas y liberar moléculas activas de manera controlada. En conclusión, aunque la piel es el órgano más extenso del cuerpo y comúnmente afectado por heridas, estas también pueden ocurrir en otras áreas debido a cirugías, tumores cancerígenos y úlceras de diversas etiologías. El desarrollo de hidrogeles con curcumina no solo se enfoca en heridas cutáneas, sino que también aborda enfermedades inflamatorias, tumores, enfermedades hepáticas, asma y osteoartritis, con aplicaciones farmacéuticas y cosméticas.

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