Fast Computational Modeling Based on the Boundary Element Method Towards the Design of an Ultrasonic Biomedical Applicator

Authors

DOI:

https://doi.org/10.17488/RMIB.46.1.1

Keywords:

acoustic field modeling, boundary element method, finite element method, focused ultrasound, ultrasonic biomedical applicators

Abstract

The aim of this work is to analyze the usage of the boundary element method (BEM) as a fast computational tool for solving large ultrasonic field problems, i.e. 3D models. A proposed tridimensional radiating surface SR was modeled by means of BEM and the finite element method (FEM).  Four time-harmonics models were developed: two containing the entire SR and two considering a symmetrical plane at half-length of the radiator. BEM solutions were validated with FEM models by contours at -3 dB and -6 dB pressure decays, areas within the contours, elliptical shape ratio Er and ellipsoidal focal volume approximations. The average differences in pressure and distance at the focus were 39.875 Pa and 0.4515 mm, respectively; the areas within the contours show differences between 0.6 mm2 and 2.3 mm2. The Er of the focal zone was over 92 %, while the ellipsoidal volume approximation showed differences between 0.0817 mm3 to 1.4632 mm3 at -3 dB, and 1.2354 mm3 to 4.1144 mm3 at -6 dB. Analyzed data suggest the use of BEM to model the ultrasonic beam pattern in a lossless medium during ultrasonic biomedical applicators design, reducing the solution time from 22 h with FEM to 2 min with BEM.

Downloads

Download data is not yet available.

References

C. R. Hill, J. C. Bamber, and G. R. ter Haar, Physical Principles of Medical Ultrasonics, 2nd ed. England: John Wiley & Sons, 2004, doi: https://doi.org/10.1002/0470093978.fmatter

D. A. Hutchins and G. Hayward, “The radiated field of ultrasonic transducers,” in Physical Acoustics, vol. 19, R. N. Thurston and A. D. Pierce, Eds., United States of America:Academic Press, 1990, pp. 1–80, doi: https://doi.org/10.1016/B978-0-12-477919-8.50007-8

C. J. Diederich and K. Hynynen, “Ultrasound technology for hyperthermia,” Ultrasound Med. Biol., vol. 25, no. 6, pp. 871–887, 1999, doi: https://doi.org/10.1016/s0301-5629(99)00048-4

G. T. Haar and C. Coussios, “High intensity focused ultrasound: Physical principles and devices,” Int. J. Hyperth., vol. 23, no. 2, pp. 89–104, 2007, doi: https://doi.org/10.1080/02656730601186138

M. Lafond, A. Payne, and C. Lafon, “Therapeutic ultrasound transducer technology and monitoring techniques: a review with clinical examples,” Int. J. Hyperth., vol. 41, no. 1, 2024, art. no. 2389288, doi: https://doi.org/10.1080/02656736.2024.2389288

C. J. Trujillo Romero and D.-L. Flores, Diagnosis and Treatment of Cancer using Thermal Therapies, 1st ed. Boca Raton, FL, United States of America: CRC Press, 2023, doi: https://doi.org/10.1201/9781003342663

E. A. Filonenko and V. A. Khokhlova, “Effect of acoustic nonlinearity on heating of biological tissue by high-intensity focused ultrasound,” Acoust. Phys., vol. 47, no. 4, pp. 468–475, 2001, doi: https://doi.org/10.1134/1.1385422

J. Gao, S. Cochran, and Z. Huang, “Ultrasound beam distortion and pressure reduction in transcostal focused ultrasound surgery,” Appl. Acoust., vol. 76, pp. 337–345, 2014, doi: https://doi.org/10.1016/j.apacoust.2013.06.003

S. Paliwal and S. Mitragotri, “Therapeutic opportunities in biological responses of ultrasound,” Ultrasonics, vol. 48, no. 4, pp. 271–278, 2008, doi: https://doi.org/10.1016/j.ultras.2008.02.002

I. Rivens, C. Jayadewa, P. Mouratidis, and G. Ter Haar, “Histological characterization of HIFU lesions,” Int. J. Hyperth., vol. 41, no. 1, 2024, art. no. 2389292, doi: https://doi.org/10.1080/02656736.2024.2389292

C. Lafon, D. Melodelima, R. Salomir, and J. Y. Chapelon, “Interstitial devices for minimally invasive thermal ablation by high-intensity ultrasound,” Int. J. Hyperthremia, vol. 23, no. 2, pp. 153–163, 2007, doi: https://doi.org/10.1080/02656730601173029

M. Dahan, M. Cortet, C. Lafon, and F. Padilla, “Combination of Focused Ultrasound, Immunotherapy, and Chemotherapy: New Perspectives in Breast Cancer Therapy,” J. Ultrasound Med., vol. 42, no. 3, pp. 559–573, 2023, doi: https://doi.org/10.1002/jum.16053

J. H. Hwang and L. A. Crum, “Current status of clinical high-intensity focused ultrasound,” in 2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Minneapolis, MN, USA, 2009, pp. 130–133. doi: https://doi.org/10.1109/iembs.2009.5335244

O. Ginsburg, C.-H. Yip, A. Brooks, A. Cabanes, et al., “Breast Cancer Early Detection: A Phased Approach to Implementation,” Cancer, vol. 126, no. S10, pp. 2379–2393, 2020, doi: https://doi.org/10.1002/cncr.32887

B. S. Bachu, J. Kedda, I. Suk, J. J. Green, and B. Tyler, “High-Intensity Focused Ultrasound: A Review of Mechanisms and Clinical Applications,” Ann. Biomed. Eng., vol. 49, pp. 1975-1991, 2021, doi: https://doi.org/10.1007/s10439-021-02833-9

Y.-H. Hsiao, S.-J. Kuo, H.-D. Tsai, M.-C. Chou, and G.-P. Yeh, “Clinical Application of High-intensity Focused Ultrasound in Cancer Therapy,” J. Cancer, vol. 7, no. 3, pp. 225–231, 2016, doi: https://doi.org/10.7150/jca.13906

E. Van ’t Wout, P. Gélat, T. Betcke, S. Arridge, and P. G. Elat, “A fast boundary element method for the scattering analysis of high-intensity focused ultrasound,” J. Acoust. Soc. Am, vol. 138, pp. 2726–2737, 2015, doi: https://doi.org/10.1121/1.4932166

F. Shen, F. Fan, F. Li, L. Wang, et al., “An efficient method for transcranial ultrasound focus correction based on the coupling of boundary integrals and finite elements,” Ultrasonics, vol. 137, 2024, art. no. 107181, doi: https://doi.org/10.1016/j.ultras.2023.107181

P. Burrascano, S. Callegari, A. Montisci, M. Ricci, and M. Versaci, Eds., Ultrasonic Nondestructive Evaluation Systems. Switzerland: Springer, 2015, doi: https://doi.org/10.1007/978-3-319-10566-6

S. Marburg, “SIX BOUNDARY ELEMENTS PER WAVELENGTH: IS THAT ENOUGH?,” J. Comput. Acoust., vol. 10, no. 01, pp. 25–51, 2002, doi: https://doi.org/10.1142/S0218396X02001401

L. L. Thompson, “A review of finite-element methods for time-harmonic acoustics,” J. Acoust. Soc. Am., vol. 119, no. 3, pp. 1315–1330, 2006, doi: https://doi.org/10.1121/1.2164987

S. R. Haqshenas, P. Gélat, E. van ’t Wout, T. Betcke, and N. Saffari, “A fast full-wave solver for calculating ultrasound propagation in the body,” Ultrasonics, vol. 110, 2021, art. no. 106240, doi: https://doi.org/10.1016/j.ultras.2020.106240

S. Kirkup, “The Boundary Element Method in Acoustics: A Survey,” Appl. Sci., vol. 9, no. 8, 2019, art. no. 1642, doi: https://doi.org/10.3390/app9081642

S. Preuss, C. Gurbuz, C. Jelich, S. K. Baydoun, and S. Marburg, “Recent Advances in Acoustic Boundary Element Methods,” J. Theor. Comput. Acoust., vol. 30, no. 03, 2022, art. no. 2240002, doi: https://doi.org/10.1142/S2591728522400023

Y. Liu, “On the BEM for acoustic wave problems,” Eng. Anal. Bound. Elem., vol. 107, pp. 53–62, 2019, doi: https://doi.org/10.1016/j.enganabound.2019.07.002

S. Marburg, “Boundary Element Method for Time-Harmonic Acoustic Problems,” in Computational Acoustics. CISM International Centre for Mechanical Sciences, M. Kaltenbacher, Ed., 2018, Switzerland: Springer, pp. 69–158, doi: https://doi.org/10.1007/978-3-319-59038-7_3

I. Harari and T. J. R. Hughes, “A cost comparison of boundary element and finite element methods for problems of time-harmonic acoustics,” Comput. Methods Appl. Mech. Eng., vol. 97, no. 1, pp. 77–102, 1992, doi: https://doi.org/10.1016/0045-7825(92)90108-V

J. Assaad, A.-C. Hladky, and B. Cugnet, “Application of the FEM and the BEM to compute the field of a transducer mounted in a rigid baffle (3D case),” Ultrasonics, vol. 42, no. 1–9, pp. 443–446, 2004, doi: https://doi.org/10.1016/j.ultras.2003.12.032

A. G. Santiago, L. C. Trintinalia, and M. A. Gutierrez, “Boundary element method applied to ultrasound elastography,” Eng. Anal. Bound. Elem., vol. 62, pp. 154–162, 2016, doi: https://doi.org/10.1016/j.enganabound.2015.10.005

P. Gélat, G. ter Haar, and N. Saffari, “Modelling of the acoustic field of a multi-element HIFU array scattered by human ribs,” Phys. Med. Biol., vol. 56, no. 17, pp. 5553–5581, 2011, doi: https://doi.org/10.1088/0031-9155/56/17/007

P. Gélat, G. ter Haar, and N. Saffari, “Towards the optimisation of acoustic fields for ablative therapies of tumours in the upper abdomen,” J. Phys. Conf. Ser., vol. 457, 2013, art. no. 012002, doi: https://doi.org/10.1088/1742-6596/457/1/012002

R. Martínez-Valdez, A. Ramos Fernández, A. Vera Hernandez, and L. Leija Salas, “Design of a low power hybrid HIFU applicator for haemostasis based on acoustic propagation modelling,” Int. J. Hyperth., vol. 32, no. 2, pp. 121–131, 2016, doi: https://doi.org/10.3109/02656736.2015.1112437

G. Ter Haar and C. Coussios, “High intensity focused ultrasound: past, present and future.,” Int. J. Hyperthermia, vol. 23, no. 2, pp. 85–7, 2007, doi: https://doi.org/10.1080/02656730601185924

H. P. Kok, E. N. K. Cressman, W. Ceelen, C. L. Brace, et al., “Heating technology for malignant tumors: a review,” Int. J. Hyperth., vol. 37, no. 1, pp. 711–741, 2020, doi: https://doi.org/10.1080/02656736.2020.1779357

C. R. Hill and G. R. ter Haar, “High intensity focused ultrasound—potential for cancer treatment,” Br. J. Radiol., vol. 68, no. 816, pp. 1296–1303, 1995, doi: https://doi.org/10.1259/0007-1285-68-816-1296

D. Melodelima, W. A. N’Djin, H. Parmentier, S. Chesnais, M. Rivoire, and J.-Y. Chapelon, “Thermal Ablation by High-Intensity-Focused Ultrasound Using a Toroid Transducer Increases the Coagulated Volume. Results of Animal Experiments,” Ultrasound Med. Biol., vol. 35, no. 3, pp. 425–435, 2009, doi: https://doi.org/10.1016/j.ultrasmedbio.2008.09.020

C. A. Cain and S. Umemura, “Concentric-Ring and Sector-Vortex Phased-Array Applicators for Ultrasound Hyperthermia,” IEEE Trans. Microw. Theory Tech., vol. 34, no. 5, pp. 542–551, 1986, doi: https://doi.org/10.1109/TMTT.1986.1133390

S. Umemura and C. A. Cain, “The sector-vortex phased array: acoustic field synthesis for hyperthermia,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control, vol. 36, no. 2, pp. 249–257, 1989, doi: https://doi.org/10.1109/58.19158

Downloads

Published

2025-01-01

How to Cite

Martínez-Valdez, R., & Bazán, I. (2025). Fast Computational Modeling Based on the Boundary Element Method Towards the Design of an Ultrasonic Biomedical Applicator. Revista Mexicana De Ingenieria Biomedica, 46(1), 6–21. https://doi.org/10.17488/RMIB.46.1.1

Issue

Section

Research Articles

Dimensions Citation